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Hot chilli production for pain medicine

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Axsain cream contains the active ingredient capsaicin, which is the substance found naturally in red chilli peppers that gives them their heat. The cream is applied to the skin to relieve nerve pain associated with shingles and with nerve damage caused by poorly controlled diabetes. Capsaicin works by desensitising nerve cells to pain. It does this by binding to sensory receptors called nociceptors that are found at the end of the nerves.
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Capsaicin applied to the skin for chronic neuropathic pain in adults | Cochrane

Qutenza contains a very high dose of capsaicin, the substance that gives red chilli peppers their 'heat'. A patch coated with a chemical derived from chilli paste is successfully treating one of the most common causes of long-term pain. It is used to treat peripheral neuropathic pain, which stems from damage to the nerves located just below the skin. Previously, patients were forced to rely on large doses of painkillers to get them through the day and night. High doses of capsaicin overstimulate the nociceptors, or pain receptors, in the skin. This action desensitises them.
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Treating Chili Burn: Your Best Solutions

Binds to nociceptors in the skin, causing neuronal excitation, heightened sensitivity and cutaneous vasodilation. Initially, a burning or pricking sensation is produced. With repeated use, a period of desensitization occurs caused by substance P depletion.
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Chili benefits the health by burning toxins from the colon. Moreover, regular consumption of chilies reduces the amount of insulin required by the body and hence, helps lower blood sugar levels after eating. Chilies have a hot, pungent flavor as they contain a substance called capsaicin.
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